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Cingal®

A unique and powerful injection therapy that delivers fast acting and long lasting relief from the pain of osteoarthritis. Used all over the world to support patients enjoy daily physical activities with reduced pain.

Cingal®

A unique and powerful injection therapy that delivers fast acting and long lasting relief from the pain of osteoarthritis. Used all over the world to support patients enjoy daily physical activities with reduced pain.

What is Cingal?

A combination therapy that safely brings together the fast acting effects of steroid with the long lasting the protective effects of hyaluronic acid. Cingal is clinically proven to delivery statistically significant knee pain relief, providing faster pain relief compared to HA alone and demonstrating superior long lasting pain relief compared to control options in blinded randomised studies. 

Cingal® in focus

Cingal® is a unique single-injection treatment proven to safely and effectively treat the pain and certain symptoms associated with osteoarthritis (OA). Cingal combines two well-established treatments in a single injection, providing the benefits of both an approved corticosteroid and a proprietary high concentration cross-linked hyaluronic acid formulation. Cingal is a simple treatment that can be peformed very quickly in an office or clinic setting. 

The corticosteroid reduces inflammation in the knee joint, providing rapid pain relief within days of injection, while the hyaluronic acid component works in parallel to deliver long-lasting pain relief proven to last through 6 months while giving protection and safety even with a steroid present. 

Only Cingal works by combining a fast-acting steroid with a long-lasting viscosupplement in one simple, convenient injection.

A knee joint affected by osteoarthritis typically has lower concentrations of hyaluronic acid in the synovial fluid, the thick liquid that helps cushion and lubricate the knee. As a result, the synovial fluid in an osteoarthritic knee has lower viscosity and elasticity than healthy synovial fluid, decreasing its ability to lubricate the joint and absorb shocks.

Hyaluronic acid (HA)-based products are designed to supplement the body’s natural HA, providing significant long-term pain relief from the symptoms of osteoarthritis.  Steroids calm inflammation very quickly, reducing pain fast but also creating the right environment for the HA to work more effectively.

The Cingal Advantage

  • Steroid provides fast short-term pain relief within days of injection
  • Steroid treats inflammation in the knee joint
  • Hyaluronic acid (HA) viscosupplement provides long lasting pain relief through 6 months
  • Convenient single-injection treatment
  • Simple procedure that can be done in a physician’s office
  • Highly concentrated, non-animal based hyaluronic acid (HA)
  • Strong safety profile in both an initial injection as well as a repeat injection1,6

Cingal evaluated in a blinded, randomised, level 1 study; 

  • 59% WOMAC PAIN REDUCTION – 1 WEEK

  • 89% RESPONSE RATE – 1 WEEK

  • 72% WOMAC PAIN REDUCTION – 26 WEEKS

  • 92% RESPONSE RATE – 26 WEEKS

CINGAL 13-01, a randomized, double-blind, placebo-controlled, active comparator Phase III study. Anika Therapeutics, Inc.: study sponsor, Dr. Laszlo Hangody: global principal investigator

We offer injection therapies for the various stages of OA

nSTRIDE®

PRP

Cingal®

Hyaluronic Acid

Steroid

Learn more about OA and joint degeneration